Pharmacokinetics of mycophenolic acid (MPA) and free MPA in paediatric renal transplant recipients-a multicentre study
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چکیده
منابع مشابه
Pharmacokinetics of mycophenolic acid (MPA) and free MPA in paediatric renal transplant recipients--a multicentre study. The German Study Group on Mycophenolate Mofetil (MMF) Therapy.
s 34 transplant, pharmacokinetic data for MPA in this time. This discrepancy can be attributed to a 35% decline (P<0.01) of the free MPA fraction from 1.4% patient population are scarce and dosage guidelines are therefore preliminary. (range 0.6–5.1%) in the initial phase post-transplant to 0.9% (range 0.5–1.9%) in the stable phase. The decrease of the free MPA fraction is probably caused Metho...
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INTRODUCTION The aim of the study was to analyse the influence of renal impairment on the pharmacokinetic parameters (PK) of mycophenolic acid (MPA) and its glucuronide metabolite (MPAG) in renal transplant recipients. MATERIAL AND METHODS The study included 43 adult patients during the maintenance period (> 6 months) following renal transplantation, treated with mycophenolate mofetil (MMF), ...
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OBJECTIVES To determine the mycophenolic acid pharmacokinetic profile early after transplant in Iranian kidney graft recipients. MATERIALS AND METHODS A cross-sectional study was performed during 6 months in 31 patients who recently had kidney transplant and received fixed doses of mycophenolate mofetil (2 g/d). The plasma levels of mycophenolic acid were determined by high performance liquid...
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ABSTRACT Background: Correction of the uremic state by a functioning allograft often restores fertility in women of reproductive age. The rate of fertility significantly differs between industrial countries, developing and middle east countries. On the other hand the results of pregnancy in Kidney Transplantation (KTP) patients are significantly better than hemodialysis patients, and pregnancy...
متن کاملLack of an effect of oral iron administration on mycophenolic acid pharmacokinetics in stable renal transplant recipients.
STUDY OBJECTIVES To determine if coadministration of polysaccharide iron complex and slow-release ferrous sulfate alter the absorption of mycophenolic acid (MPA), and to examine the potential influence of dosing relative to mycophenolate mofetil (MMF) administration and the effect of immediate- versus sustained-release iron products on the steady-state pharmacokinetics of MPA. DESIGN Prospect...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 1999
ISSN: 0931-0509,1460-2385
DOI: 10.1093/ndt/14.suppl_4.33